Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
Identifieur interne : 000B00 ( Main/Exploration ); précédent : 000A99; suivant : 000B01Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
Auteurs : N M Surina [Russie] ; T S Kalinina ; A V Volkova ; L A Malikova ; I I Poletaeva ; K S Rayevsky ; I B FedotovaSource :
- Bulletin of experimental biology and medicine ; 2011.
English descriptors
- KwdEn :
- Animals, Anti-Anxiety Agents (administration & dosage), Anti-Anxiety Agents (therapeutic use), Anticonvulsants (administration & dosage), Anticonvulsants (therapeutic use), Anxiety (complications), Anxiety (drug therapy), Anxiety (genetics), Anxiety (physiopathology), Benzimidazoles (administration & dosage), Benzimidazoles (therapeutic use), Epilepsy, Reflex (complications), Epilepsy, Reflex (drug therapy), Epilepsy, Reflex (genetics), Epilepsy, Reflex (physiopathology), Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Maze Learning (drug effects), Morpholines (administration & dosage), Morpholines (therapeutic use), Motor Activity (drug effects), Piracetam (administration & dosage), Piracetam (analogs & derivatives), Piracetam (therapeutic use), Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.
- MESH :
- chemical , administration & dosage : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- chemical , analogs & derivatives : Piracetam.
- chemical , therapeutic use : Anti-Anxiety Agents, Anticonvulsants, Benzimidazoles, Morpholines, Piracetam.
- complications : Anxiety, Epilepsy, Reflex.
- drug effects : Maze Learning, Motor Activity.
- drug therapy : Anxiety, Epilepsy, Reflex.
- genetics : Anxiety, Epilepsy, Reflex.
- physiopathology : Anxiety, Epilepsy, Reflex.
- Animals, Genetic Predisposition to Disease, Injections, Intraperitoneal, Male, Rats, Rats, Inbred Strains, Rats, Long-Evans, Rats, Wistar, Severity of Illness Index.
Abstract
We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.
PubMed: 22442800
Affiliations:
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Le document en format XML
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Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kalinina, T S" sort="Kalinina, T S" uniqKey="Kalinina T" first="T S" last="Kalinina">T S Kalinina</name></author><author><name sortKey="Volkova, A V" sort="Volkova, A V" uniqKey="Volkova A" first="A V" last="Volkova">A V Volkova</name></author><author><name sortKey="Malikova, L A" sort="Malikova, L A" uniqKey="Malikova L" first="L A" last="Malikova">L A Malikova</name></author><author><name sortKey="Poletaeva, I I" sort="Poletaeva, I I" uniqKey="Poletaeva I" first="I I" last="Poletaeva">I I Poletaeva</name></author><author><name sortKey="Rayevsky, K S" sort="Rayevsky, K S" uniqKey="Rayevsky K" first="K S" last="Rayevsky">K S Rayevsky</name></author><author><name sortKey="Fedotova, I B" sort="Fedotova, I B" uniqKey="Fedotova I" first="I B" last="Fedotova">I B Fedotova</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22442800</idno><idno type="pmid">22442800</idno><idno type="wicri:Area/PubMed/Corpus">000277</idno><idno type="wicri:Area/PubMed/Curation">000277</idno><idno type="wicri:Area/PubMed/Checkpoint">000324</idno><idno type="wicri:Area/Ncbi/Merge">000959</idno><idno type="wicri:Area/Ncbi/Curation">000959</idno><idno type="wicri:Area/Ncbi/Checkpoint">000959</idno><idno type="wicri:Area/Main/Merge">000B00</idno><idno type="wicri:Area/Main/Curation">000B00</idno><idno type="wicri:Area/Main/Exploration">000B00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.</title><author><name sortKey="Surina, N M" sort="Surina, N M" uniqKey="Surina N" first="N M" last="Surina">N M Surina</name><affiliation wicri:level="3"><nlm:affiliation>Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. opera_ghost@inbox.ru</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Biological Faculty, M. V. Lomonosov Moscow State University, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Kalinina, T S" sort="Kalinina, T S" uniqKey="Kalinina T" first="T S" last="Kalinina">T S Kalinina</name></author><author><name sortKey="Volkova, A V" sort="Volkova, A V" uniqKey="Volkova A" first="A V" last="Volkova">A V Volkova</name></author><author><name sortKey="Malikova, L A" sort="Malikova, L A" uniqKey="Malikova L" first="L A" last="Malikova">L A Malikova</name></author><author><name sortKey="Poletaeva, I I" sort="Poletaeva, I I" uniqKey="Poletaeva I" first="I I" last="Poletaeva">I I Poletaeva</name></author><author><name sortKey="Rayevsky, K S" sort="Rayevsky, K S" uniqKey="Rayevsky K" first="K S" last="Rayevsky">K S Rayevsky</name></author><author><name sortKey="Fedotova, I B" sort="Fedotova, I B" uniqKey="Fedotova I" first="I B" last="Fedotova">I B Fedotova</name></author></analytic><series><title level="j">Bulletin of experimental biology and medicine</title><idno type="e-ISSN">1573-8221</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-Anxiety Agents (administration & dosage)</term><term>Anti-Anxiety Agents (therapeutic use)</term><term>Anticonvulsants (administration & dosage)</term><term>Anticonvulsants (therapeutic use)</term><term>Anxiety (complications)</term><term>Anxiety (drug therapy)</term><term>Anxiety (genetics)</term><term>Anxiety (physiopathology)</term><term>Benzimidazoles (administration & dosage)</term><term>Benzimidazoles (therapeutic use)</term><term>Epilepsy, Reflex (complications)</term><term>Epilepsy, Reflex (drug therapy)</term><term>Epilepsy, Reflex (genetics)</term><term>Epilepsy, Reflex (physiopathology)</term><term>Genetic Predisposition to Disease</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Maze Learning (drug effects)</term><term>Morpholines (administration & dosage)</term><term>Morpholines (therapeutic use)</term><term>Motor Activity (drug effects)</term><term>Piracetam (administration & dosage)</term><term>Piracetam (analogs & derivatives)</term><term>Piracetam (therapeutic use)</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rats, Long-Evans</term><term>Rats, Wistar</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Anticonvulsants</term><term>Benzimidazoles</term><term>Morpholines</term><term>Piracetam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Piracetam</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Anxiety Agents</term><term>Anticonvulsants</term><term>Benzimidazoles</term><term>Morpholines</term><term>Piracetam</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Anxiety</term><term>Epilepsy, Reflex</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Maze Learning</term><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Anxiety</term><term>Epilepsy, Reflex</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anxiety</term><term>Epilepsy, Reflex</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Anxiety</term><term>Epilepsy, Reflex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetic Predisposition to Disease</term><term>Injections, Intraperitoneal</term><term>Male</term><term>Rats</term><term>Rats, Inbred Strains</term><term>Rats, Long-Evans</term><term>Rats, Wistar</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.</div></front></TEI><affiliations><list><country><li>Russie</li></country><region><li>District fédéral central</li></region><settlement><li>Moscou</li></settlement></list><tree><noCountry><name sortKey="Fedotova, I B" sort="Fedotova, I B" uniqKey="Fedotova I" first="I B" last="Fedotova">I B Fedotova</name><name sortKey="Kalinina, T S" sort="Kalinina, T S" uniqKey="Kalinina T" first="T S" last="Kalinina">T S Kalinina</name><name sortKey="Malikova, L A" sort="Malikova, L A" uniqKey="Malikova L" first="L A" last="Malikova">L A Malikova</name><name sortKey="Poletaeva, I I" sort="Poletaeva, I I" uniqKey="Poletaeva I" first="I I" last="Poletaeva">I I Poletaeva</name><name sortKey="Rayevsky, K S" sort="Rayevsky, K S" uniqKey="Rayevsky K" first="K S" last="Rayevsky">K S Rayevsky</name><name sortKey="Volkova, A V" sort="Volkova, A V" uniqKey="Volkova A" first="A V" last="Volkova">A V Volkova</name></noCountry><country name="Russie"><region name="District fédéral central"><name sortKey="Surina, N M" sort="Surina, N M" uniqKey="Surina N" first="N M" last="Surina">N M Surina</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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